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Different groups have demonstrated in both 6-OHDA and MPTP mice that neurodegeneration can be accelerated or decelerated through AT 1 R activation or blockade, respectively (243, 255, 258, 259)

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Supplementing with N-acetyl cysteine raises glutathione levels, the and inhibits the production of inflammatory cytokines such as TNF-alpha and interleukin-8 [33] NAC administered at doses reaching as high as 8000 mg/day, were not associated with any clinically significant adverse events